Publications of Q-GAPS Project Members in Journals, PhD Theses / Habilitations
PhD Theses/Habilitations 2021 - 2022
2022
Epidemiology and Control of Coxiella burnetii in Small Ruminants: a One Health Approach
Dr. med. vet. Benjamin Ulrich Bauer, Klinik für kleine Klauentiere und forensische Medizin und Ambulatorische Klinik, Stiftung Tierärztliche Hochschule Hannover
Genomic and internet based analysis of Coxiella burnetii
Akinyemi Mandela Fasemore, Graduate School of Life Sciences, Julius-Maximilians-University Würzburg, Section Infection and Immunity
Stärken von Human- und Veterinärmedizin gemeinsam nutzen im Kampf gegen Q-Fieber
Fenja Winter, Institut für Biometrie, Epidemiologie und Informationsverarbeitung (IBEI), WHO Collaborating Centre for Research and Training for Health at the Human-Animal-Environment Interface, Stiftung Tierärztliche Hochschule Hannover, Hannover
Clara Schoneberg, Institut für Biometrie, Epidemiologie und Informationsverarbeitung (IBEI), WHO Collaborating Centre for Research and Training for Health at the Human-Animal-Environment Interface, Stiftung Tierärztliche Hochschule Hannover, Hannover
2021
Key Maximilian Schwecht, Stiftung Tierärztliche Hochschule Hannover, Klinik für kleine Klauentiere, Hannover
Annika Wolf, Stiftung Tierärztliche Hochschule Hannover, Klinik für kleine Klauentiere, Hannover
Arne Cordsmeier, Universitätsklinikum Erlangen, Institut für Klinische Mikrobiologie, Erlangen
Svea Matthiesen, Friedrich-Loeffler-Institut, Institut für Immunologie, Greifswald - Insel Riems
Untersuchungen zur Vektorkompetenz von Zecken für Coxiella burnetii
Sophia Körner, Institut für Tierhygiene und Öffentliches Veterinärwesen der Veterinärmedizinischen Fakultät der Universität Leipzig
Publications 2019 - 2023
2024
Control of Coxiella burnetii shedding in a dairy goat herd by annual offspring vaccination
Benjamin U. Bauer, T. Louise Herms, Rico Jahnke, Nina Ossowski, Mathias C. Walter,
Dimitrios Frangoulidis, Martin Runge, Martin Ganter, Michael R. Knittler
Source: Vaccine, Volume 42, Issue 25, 14 November 2024, 126125
Detection of Coxiella burnetii in the mammary gland of a dairy goat
Benjamin Ulrich Bauer, Martin Peters, T. Louise Herms, Martin Runge, Peter Wohlsein, Tim K. Jensen & Martin Ganter
Quelle: Vet Res Commun. 2024 Jan 18. doi: 10.1007/s11259-023-10233-8
2023
Interdisciplinary studies on Coxiella burnetii: From molecular to cellular, to host, to one health research
Benjamin U. Bauer, Michael R. Knittler, Jennifer Andrack, Christian Berens, Amely Campe, Bahne Christiansen, Akinyemi M. Fasemore, Silke F. Fischer, Martin Ganter, Sophia Körner, Gustavo R. Makert, Svea Matthiesen, Katja Mertens-Scholz, Sven Rinkel, Martin Runge, Jan Schulze-Luehrmann, Sebastian Ulbert, Fenja Winter, Dimitrios Frangoulidis, Anja Lührman
Source: International Journal of Medical Microbiology 313 (2023), International Journal of Medical Microbiology 313 (2023), doi:10.1016/j.ijmm.2023.151590.:10.1016/j.ijmm.2023.151590.
Two Years after Coxiella burnetii Detection: Pathogen Shedding and Phase-Specific Antibody Response in Three Dairy Goat Herds
Christa Trachsel, Gaby Hirsbrunner, T. Louise Herms, Martin Runge, Frederik Kiene, Martin Ganter, Patrik Zanolari, Benjamin U. Bauer
Source: Animals 2023, 13(19), 3048; https://doi.org/10.3390/ani13193048
Humoral and cellular immune responses in sheep following administration of different doses of an inactivated phase I vaccine against Coxiella burnetii
Benjamin U. Bauer, Kay M. Schwecht, Rico Jahnke, Svea Matthiesen, Martin Ganter, Michael R. Knittler
Source: 23:S0264-410X(23)00746-6, https://doi.org/10.1016/j.vaccine.2023.06.061
Q Fever (Coxiella burnetii)
Roest, H.I.J., Rovers, C.P., Frangoulidis, D.
Source: Sing, A. (eds) Zoonoses: Infections Affecting Humans and Animals. Springer, Cham. (2023)
Co-exposure to Anaplasma spp., Coxiella burnetii and tick-borne encephalitis virus in sheep in southern Germany
Benjamin Ulrich Bauer, Martin Runge, Melanie Schneider, Laura Könenkamp, Imke Steffen, Wiebke Rubel, Martin Ganter, Clara Schoneberg
Source: Acta Veterinaria Scandinavica volume 65, Article number: 6 (2023)
Bovine blood derived macrophages are unable to control Coxiella burnetii replication under hypoxic conditions
Michael Mauermeir, Martha Ölke, Inaya Hayek, Jan Schulze-Luehrmann, Katja Dettmer, Peter J. Oefner, Christian Berens, Christian Menge, Anja Lührmann
Source: Front. Immunol., 30 January 2023, Sec. Microbial Immunology, Volume 14 - 2023, https://doi.org/10.3389/fimmu.2023.960927
TGF-β/IFN-γ Antagonism in Subversion and Self-Defense of Phase II Coxiella burnetii-Infected Dendritic Cells
Matthiesen S, Christiansen B, Jahnke R, Zaeck LM, Karger A, Finke S, Franzke K, Knittler MR
Source: Infect Immun. 2023 Jan 23:e0032322. doi: 10.1128/iai.00323-22. Online ahead of print.
2022
Impact of Coxiella burnetii vaccination on humoral immune response, vaginal shedding, and lamb mortality in naturally pre-infected sheep
Benjamin Ulrich Bauer, Clara Schoneberg, Thea Louise Herms, Sven Kleinschmidt, Martin Runge and Martin Ganter
Source: Front. Vet. Sci., 19 December 2022, Sec. Veterinary Infectious Disease
Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever
Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler-Tenori, Jan Schulze-Luehrmann, Michael Mauermeir, Kai-Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens-Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang
Source: EMBO Mol Med (2022)e15931
A stakeholder analysis of knowledge gaps
Fenja Winter und Amely Campe
Source: PLoS One, 2022 Mar 3;17(3):e0264629.
Surveillance of Coxiella burnetii Shedding in Three Naturally Infected Dairy Goat Herds after Vaccination, Focusing on Bulk Tank Milk and Dust Swabs
Benjamin U. Bauer, Clara Schoneberg, T. Louise Herms, Martin Runge, Martin Ganter
Source: Veterinary Sciences, Volume 9, Issue 3
The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription
Cordsmeier A, Rinkel S, Jeninga M, Schulze-Luehrmann J, Ölke M, Schmid B, Hasler D, Meister G, Häcker G, Petter M, Beare PA, Lührmann A.
Source: PLoS Pathogens 18 (2022)
Prevalence of Coxiella-infections in ticks - review and meta-analysis
Roland Eric Yessinou, Mertens-Scholz Katja, Neubauer Heinrich, Souaïbou Farougou
Source: Ticks Tick Borne Dis. 2022 Feb 16;13(3):101926.
Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma, Bartonella, Coxiella, Orientia, and Rickettsia
Vaca DJ, Dobler G, Fischer SF, Keller C, Konrad M, von Loewenich FD, Orenga S, Sapre SU, van Belkum A, Kempf VAJ
Source: FEMS Microbiol Rev. 2022 Feb 17
Coxiella burnetii
Dimitrios Frangoulidis, Mathias C. Walter, Akinyemi M. Fasemore, Sally J. Cutler
Source: Molecular Typing in Bacterial Infections, Volume II, S. 247-262
2021
CoxBase: an Online Platform for Epidemiological Surveillance, Visualization, Analysis, and Typing of Coxiella burnetii Genomic Sequences
Fasemore AM, Helbich A, Walter MC, Dandekar T, Vergnaud G, Förstner KU, Frangoulidis D.
Source: mSystems. 2021 Dec 21;6(6):e0040321
Multispecies Q Fever Outbreak in a Mixed Dairy Goat and Cattle Farm Based on a New Bovine-Associated Genotype of Coxiella burnetii
Bauer, B.U., Knittler, M.R., Herms, T.L., Frangoulidis, D., Matthiesen, S., Tappe, D., Runge, M., Ganter, M.
Source: Vet. Sci. 2021, 8, 252
Cover story: A Q fever outbreak on a mixed dairy farm - a one health approach
Bauer, B.U., Knittler, M.R., Herms, T.L., Frangoulidis, D., Matthiesen, S., Tappe, D., Runge, M., Ganter, M.
Source: Vet. Sci. 2021, 8, 252
Development of High-Throughput Multiplex Serology to Detect Serum Antibodies against Coxiella burnetii
Jeske, R., Dangel, L., Sauerbrey, L., Frangoulidis, D., Teras, L.R., Fischer, S.F., Waterboer, T.
Source: Microorganisms 2021, 9
High Prevalence and New Genotype of Coxiella burnetii in Ticks Infesting Camels in
Somalia
Dimitrios Frangoulidis; Claudia Kahlhofer; Ahmed Shire Said; Abdinasir Yusuf Osman; Lidia Chitimia-Dobler; Yassir Adam Shuaib
Source: Pathogens 2021, Volume 10, Issue 6, 741
A Straightforward Hypoxic Cell Culture Method Suitable for Standard Incubators
Svea Matthiesen, Rico Jahnke, Michael R. Knittler
Source: Methods Protoc. 2021 Apr 8;4(2):25. doi: 10.3390/mps4020025
The Prevalence of Coxiella burnetii in Hard Ticks in Europe and Their Role in Q Fever Transmission Revisited - A Systematic Review
Sophia Körner, Gustavo R Makert, Sebastian Ulbert, Martin Pfeffer, Katja Mertens-Scholz
Source: Front Vet Sci. 2021 Apr 26; 8: 655715
Mechanisms controlling bacterial infection in myeloid cells under hypoxic conditions
Inaya Hayek, Valentin Schatz, Christian Bogdan, Jonathan Jantsch, Anja Lührmann
Source: Cellular and Molecular Life Sciences (2021)
Humoral immune response to Q fever vaccination of three sheep flocks naturally pre-infected with Coxiella burnetii
Benjamin U. Bauer, Michael R. Knittler, T. Louise Prüfer, Annika Wolf, Svea Matthiesen, Martin Runge, Martin Ganter
Source: Vaccine, 10.1016/j.vaccine.2021.01.062
Concept of an Active Surveillance System for Q Fever in German Small Ruminants - Conflicts Between Best Practices and Feasibility
Fenja Winter, Clara Schoneberg, Annika Wolf, Benjamin U. Bauer, T. Louise Prüfer, Silke F. Fischer, Ursula Gerdes, Martin Runge, Martin Ganter and Amely Campe
Source: Front. Vet. Sci., 10 February 2021
An Iterative, Frequentist Approach for Latent Class Analysis to Evaluate Conditionally Dependent Diagnostic Tests
Clara Schoneberg, Lothar Kreienbrock, Amely Campe
Source: Front. Vet. Sci., 10 February 2021
Q-Fieber (Q fever)
Was Sie dazu wissen sollten! (Important to know!)
Fenja Winter und Dr. Ben Bauer
Source: Schafzucht: Das Magazin für Schaf- und Ziegenfreunde, Ausgabe 01/2021
READ FULL ARTICLE (in German)
The Coxiella burnetii effector protein CaeB modulates ER stress signaling and is required for efficient replication in Galleria mellonella
Anja Friedrich, Paul A Beare, Jan Schulze-Luehrmann, Arne Cordsmeier, Tobias Pazen, Sophia Sonnewald , Anja Lührmann
Source: Cell Microbiol. 2020 Dec 23. doi: 10.1111/cmi.13305. Online ahead of print.
2020
The Coxiella burnetii T4SS effector AnkF is important for intracellular replication
Pechstein J, Schulze-Luehrmann J, Bisle S, Cantet F, Beare PA, Ölke M, Bonazzi M, Berens C, Lührmann A. (2020) Source: Front Cell Infect Microbiol 10: 559915
CoxBase: an online platform for epidemiological surveillance, visualization, analysis and typing of Coxiella burnetii genomic sequence
Akinyemi Mandela Fasemore, Andrea Helbich, Mathias Walter, Thomas Dandekar, Gilles Vergnaud, Konrad Ulrich Foerstner, Dimitrios Frangoulidis
Source: bioRxiv 2020.11.29.402362
Risk factors for an infection with Coxiella burnetii in German sheep flocks
A. Wolf, T. L. Prüfer, C. Schoneberg, A. Campe, M. Runge, M. Ganter, B. U. Bauer
Source: Epidemiology and Infection, Volume 148
The anti-apoptotic Coxiella burnetii effector protein AnkG is a strain specific virulence factor
Walter Schäfer, Teresa Schmidt, Arne Cordsmeier, Vítor Borges, Paul A Beare, Julian Pechstein, Jan Schulze-Luehrmann, Jonas Holzinger, Nicole Wagner, Christian Berens, Carsten Heydel, João Paulo Gomes, Anja Lührmann
Source: Scientific Reports 2020 Sep 21;10(1):15396
Coxiella burnetii-infected NK cells release infectious bacteria by degranulation
Matthiesen, Svea; Zaeck, Luca Mirko; Franzke, Kati; Jahnke, Rico; Fricke, Charlie; Mauermeir, Michael; Finke, Stefan; Lührmann, Anja; Knittler, Michael R.
Source: Infect Immun. 2020 Aug 17
Comparison of Coxiella burnetii Excretion between Sheep and Goats Naturally Infected with One Cattle-Associated Genotype
Benjamin Bauer, Louise Prüfer, Mathias Walter, Isabel Ganter, Dimitrios Frangoulidis, Martin Runge and Martin Ganter
Source: Pathogens, Volume 9, Issue 8
Q-Fieber - Gemeinsam sind wir stärker!
Seminar Veterinary Public Health
F. Winter, A. Campe, L. Kreienbrock, M. Ganter, M. Runge, S. Fischer, A.Lührmann, N. Werner, S. Sprengel
Source: Deutsches Tieraerzteblatt, August 2020, S. 992 - 993
Prevalence of Coxiella burnetii in German sheepflocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level – ERRATUM
A. Wolf, T. L. Prüfer, C. Schoneberg, A. Campe, M. Runge, M. Ganter and B. U. Bauer
Source: Epidemiol Infect. 2020 Apr 27
Prevalence of Coxiella burnetii in German sheepflocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level
A. Wolf, T. L. Prüfer, C. Schoneberg, A. Campe, M. Runge, M. Ganter and B. U. Bauer
Source: Epidemiol Infect. 2020 Mar 16
Coxiella burnetii: A review with focus on infection in German sheep and goat flocks (in German)
Bauer BU, Runge M, Campe A, Henning K, Mertens-Scholz K, Boden K, Sobotta K, Frangoulidis D, Knittler MR, Matthiesen S, Berens C, Lührmann A, Fischer SF, Ulbert S, Makert GR, Ganter M. (2020)
Source: Berliner Münchner Tierärztliche Wochenschrift, 133, Heft 3/4 (2020), S. 184 - 200
Comparison of different commercially available enzyme-linked immunosorbent assays with immunofluorescence test for detection of phase II IgG and IgM antibodies to Coxiella burnetii
Dangel L, Koempf D, Fischer SF. (2020)
Source: J Clin Microbiol 58: e00951-19
Uptake and fecal excretion of Coxiella burnetii by Ixodes ricinus and Dermacentor marginatus ticks
Körner S, Makert GR, Mertens-Scholz K, Henning K, Pfeffer M, Starke A, Nijhof AM, Ulbert S (2020)
Source: Parasites & Vectors 13(1):75
2019
Defying Death – How Coxiella burnetii Copes with Intentional Host Cell Suicide
Arne Cordsmeier, Nicole Wagner, Anja Lührmann, and Christian Berens
Source: YALE JOURNAL OF BIOLOGY AND MEDICINE 92 (2019), pp.619-628
Quantitative Proteome Profiling of Coxiella burnetii Reveals Major Metabolic and Stress Differences Under Axenic and Cell Culture Cultivation
Dresler, J., J. Klimentova, P. Pajer, B. Salovska, A. M. Fucikova, M. Chmel, G. Schmoock, H. Neubauer and K. Mertens-Scholz
Source: Front Microbiol 10: 2022.
Limitation of TCA-cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages
Körner S, Mertens-Scholz K, Hayek I, Fischer F, Schulze-Lührmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A.
Source: Volume 26, Issue 13, 26 March 2019, Pages 3502-3510.e6
Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa
Samson Pandam, Salifuab Abdul-Rahman, Adamu Bukarib, Dimitrios Frangoulidis, Nick Wheelhouse
Source: Acta Tropica Volume 193, May 2019, Pages 99-105
Modulation of host cell metabolism by T4SS-encoding intracellular pathogens
Inaya Hayek, Christian Berens, Anja Lührmann.
Source: Current Opinion in Microbiology, Volume 47, February 2019, Pages 59-65
READ
Flow cytometry as a new complementary tool to study Coxiella burnetii in cell cultures
Annica Rebbig, Svea Matthiesen, Anja Lührmann, Michael R.Knittler.
Source: Journal of Microbiological Methods, Volume 151, August 2018, Pages 39-43
Q-Fieber - mehr als nur ein grippaler Infekt
Annika Glenz, Ben Bauer, Martin Ganter
Source: Der Praktische Tierarzt 99, Heft 06/2018, 601-603 (Themenheft Zoonosen, neu- und wiederauftretende Krankheiten)
Published Abstracts 2017 - 2022
2022
Q-GAPS – Q fever – GermAn Interdisciplinary Program for reSearch. Das Q-Fieber-Informations- und Forschungsnetzwerk
Dimitrios Frangoulidis, Martin Ganter, Martin Runge, Amely Campe, Katja Mertens-Scholz, Michael Knittler, Christian Berens, Anja Lührmann, Silke Fischer
Abstracts | BVÖGD/BZÖG, Fachausschuss Infektionsschutz, Workshops
Gesundheitswesen 2022; 84(04): 405
2020
Evaluation of the role of ticks in Q fever transmission
Körner S, Makert GR, Henning K, Pfeffer M, Ulbert S, Mertens K.
Zoonoses 2020 - International Symposium on Zoonoses Research, 15.-16.10.2020, Berlin, S. 32
Tick feces as a potential infection source of Q fever examined in an in vitro feeding system
Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S. 72nd Annual Meeting of the German Society for Hygiene and Microbiology (DGHM) & Annual Meeting 2020 of the Association for General and Applied Microbiology (VAAM), 08.-11.03.2020, Leipzig, S. 226, No. 306-ZOP
Ticks as a vector for Q fever – examination of the transmission of Coxiella burnetii in an artificial feeding system
Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Doktorandenforum, Leipzig, 13.02.2020, S. 22
2019
Development of methods for analyzing the vector competence of ticks in the transmission of Coxiella burnetii
Makert GR, Körner S, Mertens-Scholz K, Henning K, Nijhof A, Pfeffer M, Ulbert S.
Tagung der Deutsche Veterinärmedizinische Gesellschaft (DVG), Fachgruppe Parasitologie und parasitäre Krankheiten, 17.-19.06.2019, Leipzig, S 45-46.
Development of an in vitro feeding tool for examination of possible Q fever transmission routes in ticks
Körner S, Makert GR, Mertens-Scholz K, Henning K, Nijhof A, Pfeffer M, Ulbert S.
Tagung der Deutsche Veterinärmedizinische Gesellschaft (DVG), Fachgruppe Parasitologie und parasitäre Krankheiten, 17.-19.06.2019, Leipzig, S 203-204
Development of an in vitro feeding system for ticks as tool to explore the potential transmission routes of Q fever
Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
13th International Symposium on Ticks and Tick-borne Diseases, 28.-30.03.2019, Weimar, S 140.
2018
Development of an in vitro feeding system for modelling uptake and distribution of Coxiella burnetii in ticks
Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Junior Scientist Symposium 2018, 24.-26.09.2018, Friedrich-Loeffler-Institut (FLI), Greifswald - Insel Riems, S. 81
Development of an in vitro feeding system to investigate the role of ticks as reservoir and source for Q fever outbreaks
Makert GR, Körner S, Mertens K, Henning K, Pfeffer M, Ulbert S.
Wissenschaftliche Tagung zur Epidemiologie und Diagnostik des Q-Fiebers, 27.-28.09.2018, Friedrich-Loeffler-Institut (FLI), Jena, S. 15
Modelling uptake and organ distribution of Coxiella burnetii in ticks – development of an in vitro feeding system
Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Wissenschaftliche Tagung zur Epidemiologie und Diagnostik des Q-Fiebers, 27.-28.09.2018, Friedrich-Loeffler-Institut (FLI), Jena, S. 14
Development of an in vitro feeding system for the analysis of the vector capacity of ticks in the transmission of Coxiella burnetii
Makert GR, Körner S, Mertens K, Henning K, Pfeffer M, Ulbert S.
Workshop on Arthropod-Borne Diseases transmitted by ticks, mites, fleas, and lice, 15.-16.11.2018, Friedrich-Loeffler-Institut (FLI), Greifswald - Insel Riems, S. 11
Modelling uptake and organ distribution of Coxiella burnetii in ticks – development of an in vitro feeding system
Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Workshop on Arthropod-Borne Diseases transmitted by ticks, mites, fleas, and lice, 15.-16.11.2018, Friedrich-Loeffler-Institut (FLI), Greifswald - Insel Riems, S. 12
2017
Haben Zecken eine Bedeutung für die Übertragung von Coxiella burnetii? – Vorstellung eines Forschungsprojektes
Henning K, Makert GR, Ulbert S, Mertens K.
Gemeinsame Arbeitstagung der NRL Chlamydiose, Q-Fieber, Paratuberkulose & Tuberkulose der Rinder, 18.-20.10.2017, Friedrich-Loeffler-Institut (FLI), Jena, S. 40
Project Q-GAPS - The meaning of ticks for the transmission of Coxiella burnetii. Workshop on Arthropod-Borne Diseases transmitted by ticks, mites, fleas, and lice
Henning K, Makert GR, Ulbert S, Mertens K. 16.-17.11.2017,
Federal Research Institute for Animal Health (FLI), Jena, S. 21
