Academic Publications

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Publications of Q-GAPS Project Members in Journals, PhD Theses / Habilitations

PhD Theses 2021 - 2022

2022

Stärken von Human- und Veterinärmedizin gemeinsam nutzen im Kampf gegen Q-Fieber

Fenja Winter, Institut für Biometrie, Epidemiologie und Informationsverarbeitung (IBEI), WHO Collaborating Centre for Research and Training for Health at the Human-Animal-Environment Interface, Stiftung Tierärztliche Hochschule Hannover, Hannover


Abschätzen der diagnostischen Testgenauigkeit ohne Goldstandard bei bedingt abhängigen Tests – Methodische Entwicklung von Modellen der latenten Klassenanalyse

Clara Schoneberg, Institut für Biometrie, Epidemiologie und Informationsverarbeitung (IBEI), WHO Collaborating Centre for Research and Training for Health at the Human-Animal-Environment Interface, Stiftung Tierärztliche Hochschule Hannover, Hannover


2021

Humorale und zelluläre Immunantwort bei Schafen nach Applikation eines inaktivierten Coxiella burnetii Phase I Impfstoffes

Key Maximilian Schwecht, Stiftung Tierärztliche Hochschule Hannover, Klinik für kleine Klauentiere, Hannover


Prevalence and risk factors of Coxiella burnetii in German sheep flocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level

Annika Wolf, Stiftung Tierärztliche Hochschule Hannover, Klinik für kleine Klauentiere, Hannover


Modulation des 7SK small nuclear Ribonukleoproteinkomplexes durch das Typ-IV-Effektorprotein AnkG von Coxiella burnetii

Arne Cordsmeier, Universitätsklinikum Erlangen, Institut für Klinische Mikrobiologie, Erlangen


Charakterisierung zellautonomer Selbstverteidigung und pathogenvermittelter Gegenwehr in Coxiella burnetii-infizierten dendritischen Zellen und natürlichen Killerzellen

Svea Matthiesen, Friedrich-Loeffler-Institut, Institut für Immunologie, Greifswald - Insel Riems


Untersuchungen zur Vektorkompetenz von Zecken für Coxiella burnetii

Sophia Körner, Institut für Tierhygiene und Öffentliches Veterinärwesen der Veterinärmedizinischen Fakultät der Universität Leipzig


 

Publications 2019 - 2022

2022

A stakeholder analysis of knowledge gaps

Fenja Winter und Amely Campe
Source: PLoS One, 2022 Mar 3;17(3):e0264629.

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Surveillance of Coxiella burnetii Shedding in Three Naturally Infected Dairy Goat Herds after Vaccination, Focusing on Bulk Tank Milk and Dust Swabs

Benjamin U. Bauer, Clara Schoneberg, T. Louise Herms, Martin Runge, Martin Ganter
Source: Veterinary Sciences, Volume 9, Issue 3

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The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription

Cordsmeier A, Rinkel S, Jeninga M, Schulze-Luehrmann J, Ölke M, Schmid B, Hasler D, Meister G, Häcker G, Petter M, Beare PA, Lührmann A.
Source: PLoS Pathogens 18 (2022)

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Prevalence of Coxiella-infections in ticks - review and meta-analysis

Roland Eric Yessinou, Mertens-Scholz Katja, Neubauer Heinrich, Souaïbou Farougou
Source: Ticks Tick Borne Dis. 2022 Feb 16;13(3):101926.

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Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma, Bartonella, Coxiella, Orientia, and Rickettsia

Vaca DJ, Dobler G, Fischer SF, Keller C, Konrad M, von Loewenich FD, Orenga S, Sapre SU, van Belkum A, Kempf VAJ
Source: FEMS Microbiol Rev. 2022 Feb 17

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Coxiella burnetii

Dimitrios Frangoulidis, Mathias C. Walter, Akinyemi M. Fasemore, Sally J. Cutler
Source: Molecular Typing in Bacterial Infections, Volume II, S. 247-262

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2021

CoxBase: an Online Platform for Epidemiological Surveillance, Visualization, Analysis, and Typing of Coxiella burnetii Genomic Sequences

Fasemore AM, Helbich A, Walter MC, Dandekar T, Vergnaud G, Förstner KU, Frangoulidis D.
Source: mSystems. 2021 Dec 21;6(6):e0040321

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Multispecies Q Fever Outbreak in a Mixed Dairy Goat and Cattle Farm Based on a New Bovine-Associated Genotype of Coxiella burnetii

Bauer, B.U., Knittler, M.R., Herms, T.L., Frangoulidis, D., Matthiesen, S., Tappe, D., Runge, M., Ganter, M.
Source: Vet. Sci. 2021, 8, 252

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Multispezies Q-Fieber Ausbruch One HealthCover story: A Q fever outbreak on a mixed dairy farm - a one health approach

Bauer, B.U., Knittler, M.R., Herms, T.L., Frangoulidis, D., Matthiesen, S., Tappe, D., Runge, M., Ganter, M.
Source: Vet. Sci. 2021, 8, 252


Development of High-Throughput Multiplex Serology to Detect Serum Antibodies against Coxiella burnetii

Jeske, R., Dangel, L., Sauerbrey, L., Frangoulidis, D., Teras, L.R., Fischer, S.F., Waterboer, T.
Source: Microorganisms 2021, 9

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High Prevalence and New Genotype of Coxiella burnetii in Ticks Infesting Camels in
Somalia

Dimitrios Frangoulidis; Claudia Kahlhofer; Ahmed Shire Said; Abdinasir Yusuf Osman; Lidia Chitimia-Dobler; Yassir Adam Shuaib
Source: Pathogens 2021, Volume 10, Issue 6, 741

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A Straightforward Hypoxic Cell Culture Method Suitable for Standard Incubators

Svea Matthiesen, Rico Jahnke, Michael R. Knittler
Source: Methods Protoc. 2021 Apr 8;4(2):25. doi: 10.3390/mps4020025

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The Prevalence of Coxiella burnetii in Hard Ticks in Europe and Their Role in Q Fever Transmission Revisited - A Systematic Review

Sophia Körner, Gustavo R Makert, Sebastian Ulbert, Martin Pfeffer, Katja Mertens-Scholz
Source: Front Vet Sci. 2021 Apr 26; 8: 655715

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Mechanisms controlling bacterial infection in myeloid cells under hypoxic conditions

Inaya Hayek, Valentin Schatz, Christian Bogdan, Jonathan Jantsch, Anja Lührmann
Source: Cellular and Molecular Life Sciences (2021)

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Humoral immune response to Q fever vaccination of three sheep flocks naturally pre-infected with Coxiella burnetii

Benjamin U. Bauer, Michael R. Knittler, T. Louise Prüfer, Annika Wolf, Svea Matthiesen, Martin Runge, Martin Ganter
Source: Vaccine, 10.1016/j.vaccine.2021.01.062

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Concept of an Active Surveillance System for Q Fever in German Small Ruminants - Conflicts Between Best Practices and Feasibility

Fenja Winter, Clara Schoneberg, Annika Wolf, Benjamin U. Bauer, T. Louise Prüfer, Silke F. Fischer, Ursula Gerdes, Martin Runge, Martin Ganter and Amely Campe
Source: Front. Vet. Sci., 10 February 2021

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An Iterative, Frequentist Approach for Latent Class Analysis to Evaluate Conditionally Dependent Diagnostic Tests

Clara Schoneberg, Lothar Kreienbrock, Amely Campe
Source: Front. Vet. Sci., 10 February 2021

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Q-Fieber (Q fever)
Was Sie dazu wissen sollten! (Important to know!)

Fenja Winter und Dr. Ben Bauer
Source: Schafzucht: Das Magazin für Schaf- und Ziegenfreunde, Ausgabe 01/2021

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The Coxiella burnetii effector protein CaeB modulates ER stress signaling and is required for efficient replication in Galleria mellonella

Anja Friedrich, Paul A Beare, Jan Schulze-Luehrmann, Arne Cordsmeier, Tobias Pazen, Sophia Sonnewald , Anja Lührmann
Source: Cell Microbiol. 2020 Dec 23. doi: 10.1111/cmi.13305. Online ahead of print.

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2020

The Coxiella burnetii T4SS effector AnkF is important for intracellular replication

Pechstein J, Schulze-Luehrmann J, Bisle S, Cantet F, Beare PA, Ölke M, Bonazzi M, Berens C, Lührmann A. (2020) Source: Front Cell Infect Microbiol 10: 559915

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CoxBase: an online platform for epidemiological surveillance, visualization, analysis and typing of Coxiella burnetii genomic sequence

Akinyemi Mandela Fasemore, Andrea Helbich, Mathias Walter, Thomas Dandekar, Gilles Vergnaud, Konrad Ulrich Foerstner, Dimitrios Frangoulidis
Source: bioRxiv 2020.11.29.402362

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Risk factors for an infection with Coxiella burnetii in German sheep flocks

A. Wolf, T. L. Prüfer, C. Schoneberg, A. Campe, M. Runge, M. Ganter, B. U. Bauer
Source: Epidemiology and Infection, Volume 148

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The anti-apoptotic Coxiella burnetii effector protein AnkG is a strain specific virulence factor

Walter Schäfer, Teresa Schmidt, Arne Cordsmeier, Vítor Borges, Paul A Beare, Julian Pechstein, Jan Schulze-Luehrmann, Jonas Holzinger, Nicole Wagner, Christian Berens, Carsten Heydel, João Paulo Gomes, Anja Lührmann
Source: Scientific Reports 2020 Sep 21;10(1):15396

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Coxiella burnetii-infected NK cells release infectious bacteria by degranulation

Matthiesen, Svea; Zaeck, Luca Mirko; Franzke, Kati; Jahnke, Rico; Fricke, Charlie; Mauermeir, Michael; Finke, Stefan; Lührmann, Anja; Knittler, Michael R.
Source: Infect Immun. 2020 Aug 17

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Comparison of Coxiella burnetii Excretion between Sheep and Goats Naturally Infected with One Cattle-Associated Genotype

Benjamin Bauer, Louise Prüfer, Mathias Walter, Isabel Ganter, Dimitrios Frangoulidis, Martin Runge and Martin Ganter
Source: Pathogens, Volume 9, Issue 8

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Q-Fieber - Gemeinsam sind wir stärker!
Seminar Veterinary Public Health

F. Winter, A. Campe, L. Kreienbrock, M. Ganter, M. Runge, S. Fischer, A.Lührmann, N. Werner, S. Sprengel
Source: Deutsches Tieraerzteblatt, August 2020, S. 992 - 993


Prevalence of Coxiella burnetii in German sheepflocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level – ERRATUM

A. Wolf, T. L. Prüfer, C. Schoneberg, A. Campe, M. Runge, M. Ganter and B. U. Bauer
Source: Epidemiol Infect. 2020 Apr 27

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Prevalence of Coxiella burnetii in German sheepflocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level

A. Wolf, T. L. Prüfer, C. Schoneberg, A. Campe, M. Runge, M. Ganter and B. U. Bauer
Source: Epidemiol Infect. 2020 Mar 16

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Coxiella burnetii: A review with focus on infection in German sheep and goat flocks (in German)

Bauer BU, Runge M, Campe A, Henning K, Mertens-Scholz K, Boden K, Sobotta K, Frangoulidis D, Knittler MR, Matthiesen S, Berens C, Lührmann A, Fischer SF, Ulbert S, Makert GR, Ganter M. (2020)
Source: Berliner Münchner Tierärztliche Wochenschrift, 133, Heft 3/4 (2020), S. 184 - 200

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Comparison of different commercially available enzyme-linked immunosorbent assays with immunofluorescence test for detection of phase II IgG and IgM antibodies to Coxiella burnetii

Dangel L, Koempf D, Fischer SF. (2020)
Source: J Clin Microbiol 58: e00951-19

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Uptake and fecal excretion of Coxiella burnetii by Ixodes ricinus and Dermacentor marginatus ticks

Körner S, Makert GR, Mertens-Scholz K, Henning K, Pfeffer M, Starke A, Nijhof AM, Ulbert S (2020) 
Source: Parasites & Vectors 13(1):75

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2019

Defying Death – How Coxiella burnetii Copes with Intentional Host Cell Suicide

Arne Cordsmeier, Nicole Wagner, Anja Lührmann, and Christian Berens
Source: YALE JOURNAL OF BIOLOGY AND MEDICINE 92 (2019), pp.619-628

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Quantitative Proteome Profiling of Coxiella burnetii Reveals Major Metabolic and Stress Differences Under Axenic and Cell Culture Cultivation

Dresler, J., J. Klimentova, P. Pajer, B. Salovska, A. M. Fucikova, M. Chmel, G. Schmoock, H. Neubauer and K. Mertens-Scholz
Source: Front Microbiol 10: 2022.

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Limitation of TCA-cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages

Körner S, Mertens-Scholz K, Hayek I, Fischer F, Schulze-Lührmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A. 
Source: Volume 26, Issue 13, 26 March 2019, Pages 3502-3510.e6

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Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa

Samson Pandam, Salifuab Abdul-Rahman, Adamu Bukarib, Dimitrios Frangoulidis, Nick Wheelhouse
Source: Acta Tropica Volume 193, May 2019, Pages 99-105

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Modulation of host cell metabolism by T4SS-encoding intracellular pathogens

Inaya Hayek, Christian Berens, Anja Lührmann.
Source: Current Opinion in Microbiology, Volume 47, February 2019, Pages 59-65

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Flow cytometry as a new complementary tool to study Coxiella burnetii in cell cultures

Annica Rebbig, Svea Matthiesen, Anja Lührmann, Michael R.Knittler.
Source: Journal of Microbiological Methods, Volume 151, August 2018, Pages 39-43

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Q-Fieber - mehr als nur ein grippaler Infekt

Annika Glenz, Ben Bauer, Martin Ganter
Source: Der Praktische Tierarzt 99, Heft 06/2018, 601-603 (Themenheft Zoonosen, neu- und wiederauftretende Krankheiten)

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Published Abstracts 2017 - 2022

2022

Q-GAPS – Q fever – GermAn Interdisciplinary Program for reSearch. Das Q-Fieber-Informations- und Forschungsnetzwerk

Dimitrios Frangoulidis, Martin Ganter, Martin Runge, Amely Campe, Katja Mertens-Scholz, Michael Knittler, Christian Berens, Anja Lührmann, Silke Fischer

Abstracts | BVÖGD/BZÖG, Fachausschuss Infektionsschutz, Workshops

Gesundheitswesen 2022; 84(04): 405


 

2020

Evaluation of the role of ticks in Q fever transmission

Körner S, Makert GR, Henning K, Pfeffer M, Ulbert S, Mertens K.
Zoonoses 2020 - International Symposium on Zoonoses Research, 15.-16.10.2020, Berlin, S. 32


Tick feces as a potential infection source of Q fever examined in an in vitro feeding system

Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S. 72nd Annual Meeting of the German Society for Hygiene and Microbiology (DGHM) & Annual Meeting 2020 of the Association for General and Applied Microbiology (VAAM), 08.-11.03.2020, Leipzig, S. 226, No. 306-ZOP


Ticks as a vector for Q fever – examination of the transmission of Coxiella burnetii in an artificial feeding system

Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Doktorandenforum, Leipzig, 13.02.2020, S. 22


2019

Development of methods for analyzing the vector competence of ticks in the transmission of Coxiella burnetii

Makert GR, Körner S, Mertens-Scholz K, Henning K, Nijhof A, Pfeffer M, Ulbert S.
Tagung der Deutsche Veterinärmedizinische Gesellschaft (DVG), Fachgruppe Parasitologie und parasitäre Krankheiten, 17.-19.06.2019, Leipzig, S 45-46.


Development of an in vitro feeding tool for examination of possible Q fever transmission routes in ticks

Körner S, Makert GR, Mertens-Scholz K, Henning K, Nijhof A, Pfeffer M, Ulbert S.
Tagung der Deutsche Veterinärmedizinische Gesellschaft (DVG), Fachgruppe Parasitologie und parasitäre Krankheiten, 17.-19.06.2019, Leipzig, S 203-204


Development of an in vitro feeding system for ticks as tool to explore the potential transmission routes of Q fever

Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
13th International Symposium on Ticks and Tick-borne Diseases, 28.-30.03.2019, Weimar, S 140.


2018

Development of an in vitro feeding system for modelling uptake and distribution of Coxiella burnetii in ticks

Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Junior Scientist Symposium 2018, 24.-26.09.2018, Friedrich-Loeffler-Institut (FLI), Greifswald - Insel Riems, S. 81


Development of an in vitro feeding system to investigate the role of ticks as reservoir and source for Q fever outbreaks

Makert GR, Körner S, Mertens K, Henning K, Pfeffer M, Ulbert S.
Wissenschaftliche Tagung zur Epidemiologie und Diagnostik des Q-Fiebers, 27.-28.09.2018, Friedrich-Loeffler-Institut (FLI), Jena, S. 15


Modelling uptake and organ distribution of Coxiella burnetii in ticks – development of an in vitro feeding system

Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Wissenschaftliche Tagung zur Epidemiologie und Diagnostik des Q-Fiebers, 27.-28.09.2018, Friedrich-Loeffler-Institut (FLI), Jena, S. 14


Development of an in vitro feeding system for the analysis of the vector capacity of ticks in the transmission of Coxiella burnetii

Makert GR, Körner S, Mertens K, Henning K, Pfeffer M, Ulbert S.
Workshop on Arthropod-Borne Diseases transmitted by ticks, mites, fleas, and lice, 15.-16.11.2018, Friedrich-Loeffler-Institut (FLI), Greifswald - Insel Riems, S. 11


Modelling uptake and organ distribution of Coxiella burnetii in ticks – development of an in vitro feeding system

Körner S, Makert GR, Mertens K, Henning K, Pfeffer M, Ulbert S.
Workshop on Arthropod-Borne Diseases transmitted by ticks, mites, fleas, and lice, 15.-16.11.2018, Friedrich-Loeffler-Institut (FLI), Greifswald - Insel Riems, S. 12


2017

Haben Zecken eine Bedeutung für die Übertragung von Coxiella burnetii? – Vorstellung eines Forschungsprojektes

Henning K, Makert GR, Ulbert S, Mertens K.
Gemeinsame Arbeitstagung der NRL Chlamydiose, Q-Fieber, Paratuberkulose & Tuberkulose der Rinder, 18.-20.10.2017, Friedrich-Loeffler-Institut (FLI), Jena, S. 40


Project Q-GAPS - The meaning of ticks for the transmission of Coxiella burnetii. Workshop on Arthropod-Borne Diseases transmitted by ticks, mites, fleas, and lice

Henning K, Makert GR, Ulbert S, Mertens K. 16.-17.11.2017,
Federal Research Institute for Animal Health (FLI), Jena, S. 21


 

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